Here it comes...
Topping the agenda will be energy policy, with Mr Bush calling for a 20% cut in petrol consumption by 2017.
In excerpts released ahead of the speech - which Mr Bush is due to deliver at 0200GMT - the president describes the war on terror as a "generational struggle that will continue long after you and I have turned our duties over to others".
He proposes to set up an advisory council on the war on terror, made up of bipartisan leaders in Congress.
"We will show our enemies abroad that we are united in the goal of victory," he says.